Details:
1. Open Chrome, and in the address bar, enter "chrome://settings/content/notifications" (without the quotes) and hit enter.
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2. Go to "Allowed to send notifications" and click the Add button.
3. Enter your tenant's URL
and click "Add"
4. Restart your browser and ChemDraw application and try again. If you are prompted with the following screen, click "Open ChemDraw". You can check the "always allow" option to avoid repeating this step.
For MS Edge:
1. Go to the three dots in the upper right corner of your browser window.
2. Select Settings > Cookies and site permissions and select Notifications
3. Under Allow, click the Add button and add your tenant's URL.
4. Restart your browser and try again.