ChemBioDraw takes a long time to save a file or crashes in Mac OS 10.7 (Lion) or 10.8 (Mountain Lion)
The first thing you can try to do is repair the disk permissions. This process should help improve the performance of your machine. To perform this repair, please follow these steps: 1. Launch the Apple’s Disk Utility from the /Applications/Utilities folder. 2. After launching Disk Utility, select the desired disk—generally your startup disk—in the list to the left, then click the First Aid tab. 3. At the bottom of the First Aid panel, click the Repair Disk Permissions button. (You could instead use the Verify Disk Permissions option to preview any potential repairs before performing them, but for most users there’s little benefit from this extra step.) 4. Re-launch the ChemBioDraw and you should see and improvement in the performance.