While launching the ChemDraw application, I get a dialog to locate the ChemDraw GUI folder. How do I address this problem?

Please try the following steps:

Launch ChemDraw as an Administrator on your Windows 10 machine.
Find the Windows Start button, then Browse to ChemDraw present under ChemOffice 20XX. Select ChemDraw, then right-click, then select More | "Run as Administrator".

You will get the "Browse for Folder" dialog box to locate the "ChemDraw Items" folder. Browse to the following folder location for your version:

For v18.x
"C:\ProgramData\PerkinElmerInformatics\ChemOffice2018\ChemDraw\"

Select the ChemDraw Items folder: C:\ProgramData\PerkinElmerInformatics\ChemOffice2018\ChemDraw\ChemDraw Items, and click the OK button in the "Browse for Folder" dialog box.

For v19.x
"C:\ProgramData\PerkinElmerInformatics\ChemOffice2019\ChemDraw\"

Select the ChemDraw Items folder: C:\ProgramData\PerkinElmerInformatics\ChemOffice2019\ChemDraw\ChemDraw Items, and click the OK button in the "Browse for Folder" dialog box.

For v20.x
"C:\ProgramData\PerkinElmerInformatics\ChemOffice2020\ChemDraw\"

Select the ChemDraw Items folder: C:\ProgramData\PerkinElmerInformatics\ChemOffice2020\ChemDraw\ChemDraw Items, and click the OK button in the "Browse for Folder" dialog box.