Release Announcement – Lead Discovery Premium 3.7

Revvity Signals is delighted to announce the release of Lead Discovery Premium 3.7.

Lead Discovery Premium is powered by Spotfire and empowers scientific professionals to freely analyze chemical and biological data and create analytic applications and dashboards. Lead Discovery Premium 3.7 continues to extend capabilities for SAR analysis, whether the "S" is small molecule Structure or large molecule Sequence.

Highlights of Lead Discovery Premium 3.7 are:

· ChemCharts 4.12, including: 

o ChemCharts and Publisher are now supported on Linux (Ubuntu 22.04 and Debian 12); On-Prem only. 

o KNIME connector for integrating KNIME workflows into ChemCharts Data Functions

o HELM Matched Monomer Pairs data function

o Extract GenBank Feature data function enhances and replaces the Extract GenBank Regions data function

o Extract GenBank Regions data function is deprecated

o Biomolecule viewer and molecule viewer visualizations can now display double and triple bonds if they are defined in the underlying structure file

o Users can copy data from table visual with/without headers or transposing

o Manual sequence alignment visualization

o BILN to HELM data function

o HELM to monomer columns, extract all monomers or monomer units from HELM string to a set of columns

o HELM graph search

o Export monomer library to data table data function

o Use data table as alternative to default monomer library

o SVG rendering support for both embedded SVG and SVG URIs

o Embed Images data function now handles SVG

o Use mapped column names in Kinome Visualization

o Directed MMP sketcher shows selected portion of molecule

o Filter column indicator is shown on a column in the table visualization that is filtered by its shadow column

o Added a shadow column indicator

o Users can define a default structure search column that is preferentially selected in new structure searches in the Chemistry visualization

o Users can import/export structure searches to/from the Chemistry visualization

o Export gallery to PDF

o Antibody builder 3 option for antibody data function

o Antibody and Nanobody Dashboard interfaces expanded with additional model options

o Extract sequence from GenBank column data function

o ChemDraw style HELM rendering

o Custom color and shape rules for HELM structures

o Monomer containing text renderer

o View Only ChemCharts mode

o Protein Structure Alignment Data Function

o Nanobody Dashboard Data Function

o Add IMGT - LeFranc IMGT Antibody Numbering option

o Improve reproducibility in Antibody Structure Prediction refinement process

o Embed GenBank Data Function

o Antibody and Nanobody Structure Prediction Data Functions optimized for speed with ~15% improvement

· Updated Structure Editor with ChemDraw JS 26.1 

· Support for MDL RXN Format

· Support for Linux deployment (Debian 12 or Ubuntu 22.04)

· Various bugs addressed

Lead Discovery Premium is available through the Revvity Signals Download Center. If you do not have access to the Download Center, contact Revvity Signals Support to assist you with sign-up. Please contact your Account Manager if you are interested in purchasing.

https://revvitysignals.com/products/research/lead-discovery-premium