Open the HELM Editor in Signals

Prior to this task:

✔ Experiment must be created.

✔ ChemDraw Document must be added to an experiment.

✔ At least one HELM Monomer library must be available.

1️⃣ Signals Dashboard ➡ select [Experiments]
2️⃣ Experiments ➡ select experiment
3️⃣ Experiment Contents pane ➡ select ["chemdraw document name"]
4️⃣ ChemDraw Document section ➡ select canvas ➡ HELM ➡ select [More] ➡ select [Show HELM Editor]

Supporting Knowledge

Notes:

• The HELM Editor can be accessed from any ChemDraw Canvas.
• Biopolymer building blocks can be added, or a text string can be entered in several formats to insert a HELM structure to the canvas.
• Monomers in an existing biopolymer can be replaced or deleted.
• Selections can be made across different libraries and monomer types.
• To find and select specific monomers for replacement, use the [Find…] button in the HELM editor—all instances are selected simultaneously.
• To bulk select and replace monomers in HELM edit mode, use Shift + selection, then select a new monomer in the HELM editor.
• Structure-based monomer search can be performed alongside text search using the [Structure] button and preview panel in the Peptide, RNA/DNA, and Chem/Blob tabs. Structures can be pasted from common formats (cdxml, cdx, SMILES, molV2000/3000, InChI) and searched as substructure, similar, full, exact, or full including tautomers.