Insert a monomer(s) to a DNA/RNA sequence from the DNA/RNA tab of the HELM Editor in Signals

Prior to this task: 

✔ HELM Editor must be opened.

✔ At least one HELM Monomer library must be available.

1️⃣ HELM Editor ➡ select DNA/RNA
2️⃣ DNA/RNA tab ➡ select //  [Ribose/Base/Phosphate] ➡ select corresponding settings [“HELM Monomer library name”] [“monomer symbol”]
3️⃣ ChemDraw doc canvas ➡ select left/right bond
4️⃣ DNA/RNA tab ➡ select [“monomer symbol”]

Supporting Knowledge

Notes:

• Users can navigate through the monomers of a DNA/RNA sequence using their keyboard's arrow keys.
• Users can generate a complementary strand for a single DNA/RNA strand. From the ChemDraw Document, navigate to HELM, select [More], then select [Generate complementary strand].
• Users can auto-pair two DNA/RNA strands with maximum complementarity. From the ChemDraw Document, navigate to HELM, select [More], then select [Auto-pair].
  • The auto-pair tool works with a wide range of RNA and DNA strands, including strands that contain additional Chem or peptide monomers. It finds complementarity between strands and places hydrogen bonds between them.
• Users can show 3’ and 5’ labels for DNA/RNA sequences. From the ChemDraw Document, select the [Open panel] icon in the upper right. From the Properties tab, under Biopolymer – Labels, select the Show 3’ and 5’ checkbox.
• Users can draw individual RNA/DNA monomers by selecting "None" from the secondary monomer dropdown to draw only the primary monomer. Alternatively, use alt/option + monomer selection to add only the primary monomer (ribose, base, or phosphate) to the canvas