Signals Notebook: Is it possible to normalize the aromatic rings of compounds and reagents

Bulk import is a key function for many Signals Notebook users. However, depending on how the compounds or reagents have been exported, there may be differences in the way aromatic rings are recorded.

Possible visual representations of an aromatic ring in Signals Notebook.

The way in which these structures are exported depends on the discretion of each user. Nevertheless, does Signals Notebook have a tool that allows to normalize these structures?

Answer: Yes, Signals Notebook offers a tool to normalize the aromatic ring structures of compounds or reagents that are imported by Bulk import. To choose how the aromatic rings will be normalized, you must enter the Signals Notebook configuration and go to the "Chemistry Settings" tab and choose the option "ChemDraw Preferences".

In this menu the option "Normalize Aromatic Display" will appear. For this field you can select 3 different options:

• No Change: if the user pastes a SMILES, InChI or mol into the CDJS that is in the kekulized or Aromatic format (where applicable), then the structures are left unchanged and displayed as they are.
• Alternating Double/Single Bonds: the structure displays in Kekulized format.
• Aromatic Circles: the structure displays in aromatic format.

Note: This action must be performed by a System Administrator.

In case you want more information about this tool, we invite you to access to the System Configuration Guide > Chemistry Settings.