ChemDraw: Activation process triggers BSOD (Bug Check 0x20001 – HYPERVISOR_ERROR) on Windows 11 25H2

Q: What is the issue?

Running the ChemDraw activation script on certain Windows 11 25H2 systems may trigger a BSOD with:

“Bug Check 0x20001 – HYPERVISOR_ERROR"

Q: Which systems are affected?

Confirmed on:

• Fresh Windows 11 25H2 installations
• OS Build: 26200.8514
• HP EliteBook Series 8 G1i

Q: Which systems are not affected?

• In-place upgrades from Windows 11 23H2 to 25H2
• Systems with existing ChemDraw activations

Q: What is the root cause?

The issue appears to be related to Windows 11 25H2 (Build 26200.8514) and Hypervisor/VBS components, not ChemDraw itself.

Q: What is the recommended fix?

Install:

• 2026-06 Security Update (KB5094126)
• Updated OS Build: 26200.8655
• Release Date: June 9, 2026

Q: How do I apply the fix?

Install KB5094126 via Windows Update or deploy a newer Windows 11 image that includes the update.