AutoChrom: Resolving Runtime Error 216 After Update

Description

After updating AutoChrom (likely with WebUpdater), launching the application may result in Runtime Error 216 if the updater did not complete cleanly. This error typically occurs due to residual files, registry entries, or incomplete component installation. The resolution involves a clean uninstall, registry cleanup, and reinstallation with the latest installer, ensuring all licensed components are included.

Solution

Prerequisites

• Administrative rights are required for all steps.
• Back up the registry before making changes.
• Download the latest AutoChrom installer (e.g., ACDLabs202523_AutoChrom_Hinstall) and unzip the archive.

Steps to Resolve

1. Uninstall AutoChrom

• Go to Control Panel > Programs and Features.

• Uninstall AutoChrom.

  Note: If AutoChrom is used in a validated environment, follow your organization’s SOPs for software removal .

2. Clean Residual Files and Registry Entries

Registry Cleanup:

• Open Registry Editor (regedit).
• Back up the registry (File > Export).

• Remove two Advanced Chemistry Development folders under:

  HKEY_CURRENT_USER\Software\Advanced Chemistry Development

  HKEY_LOCAL_MACHINE\Software\Advanced Chemistry Development

File System Cleanup:

• Delete remaining AutoChrom folders in:

  C:\Program Files\ACD64

  C:\ProgramData\ACD Labs

  Note: If AutoChrom was installed in a non-default location, check that path as well.

3. Reboot the System

• Restart the computer to ensure all residual processes are cleared.

4. Reinstall AutoChrom

• Run the latest unzipped installer (e.g., ACDLabs202523_AutoChrom_Hinstall).
• Enter all registration keys at once to ensure all licensed components (e.g., Spectrus Processor, LC Simulator, PhysChem History, Percepta) are included.
• On the component selection screen, click Select All to ensure all required modules are installed.

5. Verify Installation

• Launch AutoChrom and confirm it opens without errors.

If the issue persists, repeat the steps or contact support for assistance.