CBOE Registration: Saving a record may take a long time and return error "The wait completed due to an abandoned mutex."

When Saving a Record in CBOE Web Registration, the save operation can take a long time, eventually returning an error only visible on the browser developer tools as the following:

"ExceptionMessage": "The wait completed due to an abandoned mutex.",
"ExceptionType": "System.Threading.AbandonedMutexException",
"StackTrace": " at System.Threading.WaitHandle.InternalWaitOne

This is an IIS condition that can only be cleared by performing an IISRESET on the application server.