Spectrus: Handling saturated peaks and UV/MS detector overload

Description
UV and MS detectors can saturate when analyte concentration is too high. Saturated peaks may appear flattened or clipped and yield unreliable area measurements. Spectrus can highlight such issues, but mitigation usually requires re‑acquisition.

Solution

1. In Spectrus, inspect chromatograms and mass spectra for signs of saturation:
   • The signal intensity is truncated at a fixed value, showing flat‑topped peaks.
   • Intensities at or near instrument maximum.
   • Integration results look inconsistent with expectations.
2. If saturation is confirmed:
   • Mark affected peaks as saturated or add a note in annotations.
   • Treat quantitative results from these peaks as unreliable.
3. Adjust method and re‑acquire if possible:
   • Dilute the sample.
   • Reduce injection volume.
   • Adjust detector gain or dynamic range settings (depending on the instrument).
4. Use the new, unsaturated data for quantitation and reporting.